Wu-Tang: An American Saga is set in New York City during the crack epidemic in the United States in the early 1990s. It follows the Wu-Tang Clan's formation, a vision of Bobby Diggs aka The RZA (Sanders), and its rise amid the dangers and excesses that came with the epidemic. Seeking his own way out, Diggs turns to rap in order to carve a path to fame going against his older brother Divine (Martinez), who favored the drug trade as the means to giving their family a better life. The story depicts how it all came together for the clan as Diggs unites a dozen young men who are torn between music and crime. The group battles against the forces that hold them down and these include their own occasional impulse to give up the fight.